The Cancer Cell Line Encyclopedia Enables Predictive

Such efforts should be greatly aided by robust preclinical model systems that reflect the genomic diversity of human cancers and for which detailed genetic and pharma.

The cancer cell line encyclopedia enables predictive. The cancer cell line encyclopedia enables predictive modelling of anticancer drug sensitivity. Here we describe the cancer cell line encyclopedia ccle. 1 2 3 na1 naff9. When coupled with pharmacological profiles for 24 anticancer drugs across 479 of the cell lines this collection allowed identification of genetic lineage and gene expression based predictors of drug sensitivity.

A compilation of gene expression chromosomal copy number and massively parallel sequencing data from 947 human cancer cell lines. Pdf the cancer cell line encyclopedia enables predictive modelling of anticancer drug sensitivity giordano caponigro m. 2020 the broad institute of mit harvard. This site needs javascript to work properly.

The cancer cell line encyclopedia enables predictive modelling of anticancer drug sensitivity. The cancer cell line encyclopedia enables predictive modelling of anticancer drug sensitivity. Jordi barretina the broad institute of harvard and mit cambridge massachusetts 02142 usa. The cancer cell line encyclopedia enables predictive modelling of anticancer drug sensitivity.

The cancer cell line encyclopedia enables predictive modelling of anticancer drug sensitivity. The ccle cancer cell line encyclopedia project is a collaboration between the broad institute and the novartis institutes for biomedical research and its genomics institute of the novartis research foundation to conduct a detailed genetic and pharmacologic characterization of a large panel of human cancer models to develop integrated computational analyses that link distinct pharmacologic vulnerabilities to genomic patterns and to translate cell line integrative genomics into cancer. Nicolas stransky 1 na1. Please enable it to take advantage of the complete set of features.

A compilation of gene expression chromosomal copy number and massively parallel sequencing data from 947 human cancer cell lines. Liu and jordi barretina academia edu the systematic translation of cancer genomic data into knowledge of tumour biology and therapeutic possibilities remains challenging.